NPHET has said the total number of Covid-related deaths in Ireland now stands at 5,092 - up 18 since it last reported data on deaths last Wednesday.
The Department of Health has today been notified of 2,051 more Covid-19 cases.
The number of people with the virus being treated in hospital stands at 323, up 16 from yesterday.
There are 56 Covid-19 patients in intensive care, an increase of 1 since yesterday.
The Chief Medical Officer said that while there have been increasing levels of vaccination across the population, the National Public Health Emergency Team continues "to have significant concerns over the Delta variant" of the virus and the increase in incidence of the disease.
Dr Tony Holohan said that "unfortunately" the Delta strain is still circulating widely.
"Over 70% of cases are in unvaccinated or partially vaccinated people and we are seeing a high incidence of Covid-19 in adults and teenagers aged 16-29."
He urged those who have not yet registered for a vaccine or have delayed receiving their second dose to do so as soon as possible.
"We know that vaccines work. They are about 80% effective at preventing symptomatic Covid-19 disease and they provide approximately 95% protection against hospitalisation.
"It is very important that we remain vigilant and continue to follow the public health measures that we are all so familiar with. This is especially important for anyone who is soon to return to school and college.
"Continue to wear a mask, wash your hands properly and often, maintain a social distance, manage your contacts and avoid crowds," Dr Holohan added.
A further five deaths of patients with Covid-19 have been notified in Northern Ireland, bringing the total death toll there to 2,328.
Another 1,771 further confirmed cases of the virus were also notified by the Department of Health, bringing to 11,917 the number who have tested positive in the last seven days.
Hospitals remain under intense pressure with a 104% occupancy rate.
This morning, there were 388 Covid-positive patients in hospital, of whom 43 were in intensive care. So far 2,422,194 vaccines have been administered
The latest figures came as NPHET met today to consider what advice it will give to Government ahead of the publication of a road map next week on the next phase of reopening society.
The Minister for Health has said that the roadmap will consider lifting some current restrictions in the coming weeks with others likely to be delayed until after the expected Covid-19 peak in four to six weeks time.
Speaking on RTÉ's Morning Ireland, Stephen Donnelly said it is very hard to say at this point what the situation will be at Christmas, but it is likely mask-wearing, cough etiquette and social distancing in high-risk areas will continue.
The minister said his comments yesterday that all restrictions should eased by Christmas were directed at sectors including the entertainment, religious and indoor sport sectors.
Mr Donnelly also told the programme that he would be surprised if any changes are made to the requirements for spectators at upcoming All-Ireland finals.